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You can develop folate-deficiency anemia if:

  • You don’t eat enough foods that have folic acid. These include green leafy vegetables, fresh fruits, fortified cereals, yeast, and meats (including liver).
  • You drink too much alcohol
  • You have certain diseases of the lower digestive tract, such as celiac disease. This type of anemia also occurs in people with cancer.
  • You take certain medicines, such as some used for seizures.
  • You are pregnant. This is because the developing baby needs more folic acid. Also, the mother absorbs it more slowly. A lack of folate during pregnancy is linked to major birth defects that affect the brain, spinal cord, and spine (neural tube defects).

What are the symptoms of folate-deficiency anemia?

  • Pale skin
  • Decreased appetite
  • Being grouchy (irritable)
  • Lack of energy or tiring easily
  • Diarrhea
  • Smooth and tender tongue

The symptoms of folate-deficiency anemia may look like other blood conditions or health problems. Always see your healthcare provider for a diagnosis.

How is folate-deficiency anemia treated?

Your healthcare provider will figure out the best treatment based on:

  • Your age, overall health, and medical history
  • How sick you are
  • How well you can handle certain medicines, treatments, or therapies
  • How long the condition is expected to last
  • Your opinion or preference

Treatment may include:

  • Vitamin and mineral supplements
  • Changes in your diet
  • Medicine
  • Treating the underlying disease

You may need to take folic acid supplements for at least 2 to 3 months. These may be pills or shots (injections). Eating foods high in folic acid and cutting your alcohol intake are also important. If a digestive tract problem causes your anemia, your provider may treat that first.

Key points about folate-deficiency anemia

  • Most folate-deficiency anemia is caused by a lack of folic acid in the diet.
  • Leafy vegetables, citrus fruits, beans, and whole grains are natural sources of folic acid.
  • Folate-deficiency anemia in pregnancy may cause a neural tube defect. This is when the brain or spinal cord doesn’t develop normally.
  • Treatment includes a well-balanced diet of foods with folic acid, folic acid supplements, medicines, and treating underlying diseases.

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